Publications

2013

2012

I. Santin, F. Moore, F.A. Grieco, P Marchetti, C. Brancolini, D.L. Eizirik. Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Cell Death Dis. 2012 Nov 15.
PubMed 23152055

D.L. Eizirik, M. Miani, A.K. Cardozo. Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia. 2012 Nov 7. [Epub ahead of print]
PubMed 23132339

D.L. Eizirik, M. Cnop. Mining Genes in Type 2 Diabetic Islets and Finding Gold. Cell Metabolism, Volume 16, Issue 5, 555-557, 2012 Nov 7.
PubMed 23140638

D.A. Cunha, M. Igoillo-Esteve, E.N. Gurzov, C.M. Germano, N. Naamane, I. Marhfour, M. Fukaya, J.M. Vanderwinden, C. Gysemans, C. Mathieu, L. Marselli, P. Marchetti, H.P. Harding, D. Ron, D.L. Eizirik, M. Cnop. Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis. Diabetes. 2012 Jul 6. [Epub ahead of print]
PubMed 22773666

I. Marhfour, X. M. Lopez, D. Lefkaditis, I. Salmon, F. Allagnat, S. J. Richardson, N. G. Morgan, D. L. Eizirik. Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia, (2012).
PubMed 22699564

F. Allagnat, M. Fukaya, T. C. Nogueira, D. Delaroche, N. Welsh, L. Marselli, P. Marchetti, J. A. Haefliger, D. L. Eizirik, A. K. Cardozo. C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells. Cell Death Differ., (2012).
PubMed 22653339

F. Ortis, M. Miani, M. L. Colli, D. A. Cunha, E. N. Gurzov, F. Allagnat, A. Chariot, D. L. Eizirik. Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells. FEBS Lett., 586:984-989 (2012).
PubMed 22569251

M. Miani, M. L. Colli, L. Ladrière, M. Cnop, D. L. Eizirik. Mild Endoplasmic Reticulum Stress Augments the Proinflammatory Effect of IL-1β in Pancreatic Rat β-Cells via the IRE1α/XBP1s Pathway. Endocrinology, 153:3017-3028 (2012).
PubMed 22529213

D. L. Eizirik, M. Sammeth, T. Bouckenooghe, G. Bottu, G. Sisino, M. Igoillo-Esteve, F. Ortis, I. Santin, M. L. Colli, J. Barthson, L. Bouwens, L. Hughes, L. Gregory, G. Lunter, L. Marselli, P. Marchetti, M. I. McCarthy, M. Cnop. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet., 8:e100255 (2012).
PubMed 22412385

K. Andralojc, M. Srinivas, M. Brom, L. Joosten, I. J. de Vries, D. L. Eizirik, O. C. Boerman, P. Meda, M. Gotthardt. Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis. Diabetologia, 55:1247-1257 (2012).
PubMed 22358499

F. Moore, I. Santin, T. C. Nogueira, E. N. Gurzov, L. Marselli, P. Marchetti, D. L. Eizirik. The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells. PLoS One, 7:e31062 (2012).
PubMed 22347430

M. Volkmar, S. Dedeurwaerder, D. A. Cunha, M. N. Ndlovu, M. Defrance, R. Deplus, E. Calonne, U. Volkmar, M. Igoillo-Esteve, N. Naamane, S. Del Guerra, M. Masini, M. Bugliani, P. Marchetti, M. Cnop, D. L. Eizirik, F. Fuks. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J., 31: 1405-1426 (2012).
PubMed 22293752

M. Maris, L. Overbergh, C. Gysemans, A.Waget, A. K. Cardozo, E. Verdrengh, J. P. Cunha, T. Gotoh, M. Cnop, D. L. Eizirik, R. Burcelin, C. Mathieu. Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance. Diabetologia, 55:1167-1178 (2012).
PubMed 22237685

F. Moore, D. A. Cunha, H. Mulder, D. L. Eizirik. Use of RNA interference to investigate cytokine signal transduction in pancreatic Beta cells, Methods Mol. Biol., 820:179-194 (2012).
PubMed 22131032

2011

H. Kolb, D. L. Eizirik. Resistance to type 2 diabetes mellitus: a matter of hormesis? Nat. Rev. Endocrinol., 8:183-92 (2011).
PubMed 22024974

I. Santin, F. Moore, M. L. Colli, E. N. Gurzov, L. Marselli, P. Marchetti, D. L. Eizirik. PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim, Diabetes, 60:3279-3288 (2011).
PubMed 21984578

M. L. Colli, T. C. Nogueira, F. Allagnat, D. A. Cunha, E. N. Gurzov, A. K. Cardozo, M. Roivainen, A. Op de Beeck, D. L. Eizirik. Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance, PLoS Pathog., 7:e1002267 (2011).
PubMed 21977009

M. Cnop, F. Foufelle, L. A. Velloso. Endoplasmic reticulum stress, obesity and diabetes, Trends Mol Med., 18:59-68 (2011).
PubMed 21889406

J. Barthson, C. M. Germano, F. Moore, A. Maida, D. J. Drucker, P. Marchetti, C. Gysemans, C. Mathieu, G. Nunez, A. Jurisicova, D. L. Eizirik, E. N. Gurzov. Tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim activation, J. Biol. Chem., 286:39632-39643 (2011).
PubMed 21937453

E. N. Gurzov, J. Barthson, I. Marhfour, F. Ortis, N. Naamane, M. Igoillo-Esteve, C. Gysemans, C. Mathieu, S. Kitajima, P. Marchetti, T. F. Ørntoft, L. Bakiri, E. F. Wagner, D. L. Eizirik. Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation, Oncogene, 31:1723-1732 (2011).
PubMed 21841823

M. Cnop, M. Igoillo-Esteve, S. J. Hughes, J. N. Walker, I. Cnop, A. Clark. Longevity of human islet α- and β-cells, Diabetes, Obes. Metab., Suppl., 1:39-46 (2011).
PubMed 21824255

B. B. Johansson, J. Torsvik, L. Bjørkhaug, M. Vesterhus, A. Ragvin, E. Tjora, K. Fjeld, D. Hoem, S. Johansson, H. Ræder, S. Lindquist, O. Hernell, M. Cnop, J. Saraste, T. Flatmark, A. Molven, P. R. Njølstad. Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl-ester lipase gene (CEL-MODY): a protein misfolding disease, J. Biol. Chem., 286:34593-34605 (2011).
PubMed 21784842

M. Maris, E. Waelkens, M. Cnop, W. D'Hertog, D. A. Cunha, H. Korf, T. Koike, L. Overbergh, C. Mathieu. Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid, J. Proteome Res., 10:3372-3385 (2011).
PubMed 21707097

L. A. Berchtold, Z. M. Størling, F. Ortis, K. Lage, C. Bang-Berthelsen, R. Bergholdt, J. Hald, C. A. Brorsson, D. L. Eizirik, F. Pociot, S. Brunak and J. Storling. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and β-cell apoptosis, Proc. Natl. Acad. Sci. U. S. A., 108:E681-E688 (2011).
PubMed 21705657

S. Arif, F. Moore, K. Marks, T. Bouckenooghe, C. M. Dayan, R. Planas, M. Vives-Pi, J. Powrie, T. Tree, P. Marchetti, G. C. Huang, E. N. Gurzov, R. Pujol-Borrell, D. L. Eizirik and M. Peakman. Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death, Diabetes, 60:2112-2119 (2011).
PubMed 21659501

E. Nguidjoe, S. Sokolow, S. Bigabwa, N. Pachera, F. Allagnat, J. M. Vanderwinden, A. Sener, M. Manto, M.Depreter, J. Mast, G. Joanny, E. Montanya, J. Rahier, A. K. Cardozo, D. L. Eizirik, S. Schurmans and A. Herchuelz. Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass, Diabetes, 60:2076-2085 (2011).
PubMed 21659499

E. N. Gurzov and D. L. Eizirik. Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction, Trends Cell Biol., 21:424-431 (2011).
PubMed 21481590

M. Igoillo-Esteve, E. N. Gurzov, D. L. Eizirik, and M. Cnop. The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic β-cell inflammatory responses, Endocrinology, 152:447-456 (2011).
PubMed 21190961

F. Moore, N. Naamane, M. L. Colli, T. Bouckenooghe, F. Ortis, E. N. Gurzov, M. Igoillo-Esteve, C. Mathieu, G. Bontempi, T. Thykjaer, T. F. Ørntoft, and D. L. Eizirik. STAT1 is a master regulator of pancreatic β-cell apoptosis and islet inflammation, J. Biol. Chem., 286:929-941 (2011).
PubMed 20980260

F. Allagnat, D. Cunha, F. Moore, J. M. Vanderwinden, D. L. Eizirik, and A. K. Cardozo. Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis, Cell Death Differ., 18:328-337 (2011).
PubMed 20798690

K. Lemaire, R. F. Moura, M. Granvik, M. Igoillo-Esteve, H. E. Hohmeier, N. Hendrickx, C. B. Newgard, E. Waelkens, M. Cnop, and F. Schuit. Ubiquitin Fold Modifier 1 (UFM1) and Its Target UFBP1 Protect Pancreatic Beta Cells from ER Stress-Induced Apoptosis, PLoS One, 6:e18517 (2011).
PubMed 21494687

2010

R. Liechti, G. Csardi, S. Bergmann, F. Schutz, T. Sengstag, S. F. Boj, J. M. Servitja, J. Ferrer, L. Van Lommel, F. Schuit, S. Klinger, B. Thorens, N. Naamane, D. L. Eizirik, L. Marselli, M. Bugliani, P. Marchetti, S. Lucas, C. Holm, C. V. Jongeneel, and I. Xenarios. EuroDia: a beta-cell gene expression resource, Database. (Oxford), 2010:baq024 (2010).
PubMed 20940178

W. D'Hertog, M. Maris, G. B. Ferreira, E. Verdrengh, K. Lage, D. A. Hansen, A. K. Cardozo, C. T. Workman, Y. Moreau, D. L. Eizirik, E. Waelkens, L. Overbergh, and C. Mathieu. Novel insights into the global proteome responses of insulin-producing INS-1E cells to different degrees of endoplasmic reticulum stress, J. Proteome Res., 9:5142-5152 (2010).
PubMed 20839851

L. Jiang, F. Allagnat, E. Nguidjoe, A. Kamagate, N. Pachera, J. M. Vanderwinden, M. Brini, E. Carafoli, D. L. Eizirik, A. K. Cardozo, and A. Herchuelz. Plasma membrane Ca²⁺-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca²⁺ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells, J. Biol. Chem., 285:30634-30643 (2010).
PubMed 20660595

E. N. Gurzov, C. M. Germano, D. A. Cunha, F. Ortis, J. M. Vanderwinden, P. Marchetti, L. Zhang, and D. L. Eizirik. p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic β-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress, J. Biol. Chem., 285:19910-19920 (2010).
PubMed 20421300

D. Flamez, I. Roland, A. Berton, B. Kutlu, D. Dufrane, M. C. Beckers, E. De Waele, I. Rooman, L. Bouwens, A. Clark, M. Lonneux, J. F. Jamar, S. Goldman, D. Marechal, N. Goodman, P. Gianello, C. Van Huffel, I. Salmon, and D. L. Eizirik. A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker, Diabetologia, 53:1372-1383 (2010).
PubMed 20379810

M. Igoillo-Esteve, L. Marselli, D. A. Cunha, L. Ladrière, F. Ortis, F. A. Grieco, F. Dotta, G. C. Weir, P. Marchetti, D. L. Eizirik, and M. Cnop. Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes, Diabetologia, 53:1395-1405 (2010).
PubMed 20369226

F. Allagnat, F. Christulia, F. Ortis, P. Pirot, S. Lortz, S. Lenzen, D. L. Eizirik, and A. K. Cardozo. Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis, Diabetologia, 53:1120-1130 (2010).
PubMed 20349222

D. L. Eizirik and M. Cnop. ER stress in pancreatic β cells: the thin red line between adaptation and failure, Sci. Signal., 3:pe7 (2010).
PubMed 20179270

T. Bouckenooghe, D. Flamez, F. Ortis, S. Goldman, and D. L. Eizirik. Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach, Curr. Pharm. Des, 16:1609-1618 (2010).
PubMed 20146665

L. Ladrière, M. Igoillo-Esteve, D. A. Cunha, J. P. Brion, M. Bugliani, P. Marchetti, D. L. Eizirik, and M. Cnop. Enhanced signaling downstream of ribonucleic acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets, J. Clin. Endocrinol. Metab, 95:1442-1449 (2010).
PubMed 20080856

F. Ortis, N. Naamane, D. Flamez, L. Ladrière, F. Moore, D. A. Cunha, M. L. Colli, T. Thykjaer, K. Thorsen, T. F. Ørntoft, and D. L. Eizirik. Cytokines interleukin-1β and tumor necrosis factor-α regulate different transcriptional and alternative splicing networks in primary β-cells, Diabetes, 59:358-374 (2010).
PubMed 19934004

M. L. Colli, F. Moore, E. N. Gurzov, F. Ortis, and D. L. Eizirik. MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA, Hum. Mol. Genet., 19:135-146 (2010).
PubMed 19825843

M. Cnop, L. Ladrière, M. Igoillo-Esteve, R. F. Moura, and D. A. Cunha. Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction, Diabetes Obes. Metab, 12 Suppl 2:76-82 (2010).
PubMed 21029303

M. Maris, G. B. Ferreira, W. D'Hertog, M. Cnop, E. Waelkens, L. Overbergh, and C. Mathieu. High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach, J. Proteome Res., 9:6274-6287 (2010).
PubMed 20942503

D. Martinovici, V. Ransy, S. Vanden Eijnden, C. Ridremont, A. Pardou, M. Cassart, F. Avni, C. Donner, P. Lingier, A. Mathieu, B. Gulbis, B. De, V, M. Cnop, M. Abramowicz, and J. Desir. Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn, Eur. J. Med. Genet., 53:25-28 (2010).
PubMed 19887127

M. Cnop, S. J. Hughes, M. Igoillo-Esteve, M. B. Hoppa, F. Sayyed, L. L. van de, J. H. Gunter, E. J. de Koning, G. V. Walls, D. W. Gray, P. R. Johnson, B. C. Hansen, J. F. Morris, M. Pipeleers-Marichal, I. Cnop, and A. Clark. The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation, Diabetologia, 53:321-330 (2010).
PubMed 19855953

2009

C. Gysemans, H. Callewaert, F. Moore, M. Nelson-Holte, L. Overbergh, D. L. Eizirik, and C. Mathieu. Interferon regulatory factor-1 is a key transcription factor in murine beta cells under immune attack, Diabetologia, 52:2374-2384 (2009).
PubMed 19756487

M. Garcia, Z. Dogusan, F. Moore, S. Sato, G. Hartmann, D. L. Eizirik, and J. Rasschaert. Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells, Biochim. Biophys. Acta, 1793:1768-1775 (2009).
PubMed 19747951

D. A. Cunha, L. Ladrière, F. Ortis, M. Igoillo-Esteve, E. N. Gurzov, R. Lupi, P. Marchetti, D. L. Eizirik, and M. Cnop. Glucagon-like peptide-1 agonists protect pancreatic β-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB, Diabetes, 58:2851-2862 (2009).
PubMed 19720788

E. N. Gurzov, F. Ortis, D. A. Cunha, G. Gosset, M. Li, A. K. Cardozo, and D. L. Eizirik. Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis, Cell Death Differ., 16:1539-1550 (2009).
PubMed 19629134

M. F. Tonnesen, L. G. Grunnet, J. Friberg, A. K. Cardozo, N. Billestrup, D. L. Eizirik, J. Storling, and T. Mandrup-Poulsen. Inhibition of nuclear factor-κB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells, Endocrinology, 150:4094-4103 (2009).
PubMed 19556421

N. Li, T. Brun, M. Cnop, D. A. Cunha, D. L. Eizirik, and P. Maechler. Transient oxidative stress damages mitochondrial machinery inducing persistent β-cell dysfunction, J. Biol. Chem., 284:23602-23612 (2009).
PubMed 19546218

D. L. Eizirik, M. L. Colli, and F. Ortis. The role of inflammation in insulitis and β-cell loss in type 1 diabetes, Nat. Rev. Endocrinol., 5:219-226 (2009).
PubMed 19352320

F. Moore, M. L. Colli, M. Cnop, M. I. Esteve, A. K. Cardozo, D. A. Cunha, M. Bugliani, P. Marchetti, and D. L. Eizirik. PTPN2, a candidate gene for type 1 diabetes, modulates interferon-γ-induced pancreatic β-cell apoptosis, Diabetes, 58:1283-1291 (2009).
PubMed 19336676

D. L. Eizirik. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes: response to Nathan et al, Diabetes Care, 32:e35-e36 (2009).
PubMed 19246586

B. Kutlu, D. Burdick, D. Baxter, J. Rasschaert, D. Flamez, D. L. Eizirik, N. Welsh, N. Goodman, and L. Hood. Detailed transcriptome atlas of the pancreatic beta cell, BMC. Med. Genomics, 2:3 (2009).
PubMed 19146692

D. L. Eizirik. Guidelines for medical management of hyperglycaemia in type 2 diabetes and duality of interest, Diabetologia, 52:550-551 (2009).
PubMed 19034415

M. L. Jacobsen, S. G. Ronn, C. Bruun, C. M. Larsen, D. L. Eizirik, T. Mandrup-Poulsen, and N. Billestrup. IL-1β-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells, Diabetologia, 52:281-288 (2009).
PubMed 19002429

2008

M. Cnop, M. Igoillo-Esteve, D. A. Cunha, L. Ladrière, and D. L. Eizirik. An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells, Biochem. Soc. Trans., 36:909-915 (2008).
PubMed 18793160

E. N. Gurzov, F. Ortis, L. Bakiri, E. F. Wagner, and D. L. Eizirik. JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells, PLoS. One., 3:e3030 (2008).
PubMed 18716665

D. A. Cunha, P. Hekerman, L. Ladrière, A. Bazarra-Castro, F. Ortis, M. C. Wakeham, F. Moore, J. Rasschaert, A. K. Cardozo, E. Bellomo, L. Overbergh, C. Mathieu, R. Lupi, T. Hai, A. Herchuelz, P. Marchetti, G. A. Rutter, D. L. Eizirik, and M. Cnop. Initiation and execution of lipotoxic ER stress in pancreatic β-cells, J. Cell Sci., 121:2308-2318 (2008).
PubMed 18559892

D. L. Eizirik, F. Moore, D. Flamez, and F. Ortis. Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes, Biochem. Soc. Trans., 36:321-327 (2008).
PubMed 18481950

F. Ortis, P. Pirot, N. Naamane, A. Y. Kreins, J. Rasschaert, F. Moore, E. Theatre, C. Verhaeghe, N. E. Magnusson, A. Chariot, T. F. Ørntoft, and D. L. Eizirik. Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells, Diabetologia, 51:1213-1225 (2008).
PubMed 18463842

P. Pirot, A. K. Cardozo, and D. L. Eizirik. Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes, Arq Bras. Endocrinol. Metabol., 52:156-165 (2008).
PubMed 18438526

Z. Dogusan, M. Garcia, D. Flamez, L. Alexopoulou, M. Goldman, C. Gysemans, C. Mathieu, C. Libert, D. L. Eizirik, and J. Rasschaert. Double-stranded RNA induces pancreatic β-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways, Diabetes, 57:1236-1245 (2008).
PubMed 18223009

D. L. Eizirik, A. K. Cardozo, and M. Cnop. The role for endoplasmic reticulum stress in diabetes mellitus, Endocr. Rev., 29:42-61 (2008).
PubMed 18048764

A. J. Guri, R. Hontecillas, G. Ferrer, O. Casagran, U. Wankhade, A. M. Noble, D. L. Eizirik, F. Ortis, M. Cnop, D. Liu, H. Si, and J. Bassaganya-Riera. Loss of PPARγ in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue, J. Nutr. Biochem., 19:216-228 (2008).
PubMed 17618105

E. Louagie, N. A. Taylor, D. Flamez, A. J. Roebroek, N. A. Bright, S. Meulemans, R. Quintens, P. L. Herrera, F. Schuit, W. J. Van de Ven, and J. W. Creemers. Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate, Proc. Natl. Acad. Sci. U. S. A., 105:12319-12324 (2008).
PubMed 18713856

2007

W. D'Hertog, L. Overbergh, K. Lage, G. B. Ferreira, M. Maris, C. Gysemans, D. Flamez, A. K. Cardozo, B. G. Van den, L. Schoofs, L. Arckens, Y. Moreau, D. A. Hansen, D. L. Eizirik, E. Waelkens, and C. Mathieu. Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved, Mol. Cell Proteomics., 6:2180-2199 (2007).
PubMed 17921177

P. Marchetti, M. Bugliani, R. Lupi, L. Marselli, M. Masini, U. Boggi, F. Filipponi, G. C. Weir, D. L. Eizirik, and M. Cnop. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients, Diabetologia, 50:2486-2494 (2007).
PubMed 17906960

H. Callewaert, C. Gysemans, A. K. Cardozo, M. Elsner, M. Tiedge, D. L. Eizirik, and C. Mathieu. Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes, Cell Transplant., 16:527-537 (2007).
PubMed 17708342

A. K. Cardozo, V. Buchillier, M. Mathieu, J. Chen, F. Ortis, L. Ladrière, N. Allaman-Pillet, O. Poirot, S. Kellenberger, J. S. Beckmann, D. L. Eizirik, C. Bonny, and F. Maurer. Cell-permeable peptides induce dose- and length-dependent cytotoxic effects, Biochim. Biophys. Acta, 1768:2222-2234 (2007).
PubMed 17626783

H. I. Callewaert, C. A. Gysemans, L. Ladrière, W. D'Hertog, J. Hagenbrock, L. Overbergh, D. L. Eizirik, and C. Mathieu. Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection, Diabetes, 56:2169-2173 (2007).
PubMed 17473223

P. Pirot, F. Ortis, M. Cnop, Y. Ma, L. M. Hendershot, D. L. Eizirik, and A. K. Cardozo. Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells, Diabetes, 56:1069-1077 (2007).
PubMed 17395747

P. Pirot, N. Naamane, F. Libert, N. E. Magnusson, T. F. Ørntoft, A. K. Cardozo, and D. L. Eizirik. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs, Diabetologia, 50:1006-1014 (2007).
PubMed 17333111

N. Naamane, J. van Helden, and D. L. Eizirik. In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells, BMC Bioinformatics, 8:55 (2007).
PubMed 17302974

E. M. Hulbert, L. J. Smink, E. C. Adlem, J. E. Allen, D. B. Burdick, O. S. Burren, V. M. Cassen, C. C. Cavnor, G. E. Dolman, D. Flamez, K. F. Friery, B. C. Healy, S. A. Killcoyne, B. Kutlu, H. Schuilenburg, N. M. Walker, J. Mychaleckyj, D. L. Eizirik, L. S. Wicker, J. A. Todd, and N. Goodman. T1DBase: integration and presentation of complex data for type 1 diabetes research, Nucleic Acids Res., 35:D742-D746 (2007).
PubMed 17169983

M. Cnop, L. Ladrière, P. Hekerman, F. Ortis, A. K. Cardozo, Z. Dogusan, D. Flamez, M. Boyce, J. Yuan, and D. L. Eizirik. Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis, J. Biol. Chem., 282:3989-3997 (2007).
PubMed 17158450

2006

I. Kharroubi, C. H. Lee, P. Hekerman, M. I. Darville, R. M. Evans, D. L. Eizirik, and M. Cnop. BCL-6: a possible missing link for anti-inflammatory PPAR-δ signalling in pancreatic beta cells, Diabetologia, 49:2350-2358 (2006).
PubMed 16896941

P. Pirot, D. L. Eizirik, and A. K. Cardozo. Interferon-γ potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms, Diabetologia, 49:1229-1236 (2006).
PubMed 16604358

F. Ortis, A. K. Cardozo, D. Crispim, J. Storling, T. Mandrup-Poulsen, and D. L. Eizirik. Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-κB activation, Mol. Endocrinol., 20:1867-1879 (2006).
PubMed 16556731

R. Eldor, A. Yeffet, K. Baum, V. Doviner, D. Amar, Y. Ben Neriah, G. Christofori, A. Peled, J. C. Carel, C. Boitard, T. Klein, P. Serup, D. L. Eizirik, and D. Melloul. Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents, Proc. Natl. Acad. Sci. U. S. A, 103:5072-5077 (2006).
PubMed 16551748

M. I. Darville and D. L. Eizirik. Notch signaling: a mediator of β-cell de-differentiation in diabetes?, Biochem. Biophys. Res. Commun., 339:1063-1068 (2006).
PubMed 16337608

2005

N. E. Magnusson, A. K. Cardozo, M. Kruhoffer, D. L. Eizirik, T. F. Ørntoft, and J. L. Jensen. Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis, BMC. Bioinformatics., 6:311 (2005).
PubMed 16384535

M. Cnop, N. Welsh, J. C. Jonas, A. Jorns, S. Lenzen, and D. L. Eizirik. Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities, Diabetes, 54 Suppl 2:S97-107 (2005).
PubMed 16306347

L. Larsen, J. Storling, M. Darville, D. L. Eizirik, C. Bonny, N. Billestrup, and T. Mandrup-Poulsen. Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor κB-mediated gene expression in insulin-producing INS-1E cells, Diabetologia, 48:2582-2590 (2005).
PubMed 16283237

N. Welsh, M. Cnop, I. Kharroubi, M. Bugliani, R. Lupi, P. Marchetti, and D. L. Eizirik. Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?, Diabetes, 54:3238-3244 (2005).
PubMed 16249450

D. Guo, J. Han, B. L. Adam, N. H. Colburn, M. H. Wang, Z. Dong, D. L. Eizirik, J. X. She, and C. Y. Wang. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress, Biochem. Biophys. Res. Commun., 337:1308-1318 (2005).
PubMed 16236267

C. A. Gysemans, L. Ladrière, H. Callewaert, J. Rasschaert, D. Flamez, D. E. Levy, P. Matthys, D. L. Eizirik, and C. Mathieu. Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of β-cells, Diabetes, 54:2396-2403 (2005).
PubMed 16046307

J. Rasschaert, L. Ladrière, M. Urbain, Z. Dogusan, B. Katabua, S. Sato, S. Akira, C. Gysemans, C. Mathieu, and D. L. Eizirik. Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-γ-induced apoptosis in primary pancreatic β-cells, J. Biol. Chem., 280:33984-33991 (2005).
PubMed 16027122

P. Ylipaasto, B. Kutlu, S. Rasilainen, J. Rasschaert, K. Salmela, H. Teerijoki, O. Korsgren, R. Lahesmaa, T. Hovi, D. L. Eizirik, T. Otonkoski, and M. Roivainen. Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets, Diabetologia, 48:1510-1522 (2005).
PubMed 15991020

M. Li, D. Guo, C. M. Isales, D. L. Eizirik, M. Atkinson, J. X. She, and C. Y. Wang. SUMO wrestling with type 1 diabetes, J. Mol. Med., 83:504-513 (2005).
PubMed 15806321

H. Elouil, A. K. Cardozo, D. L. Eizirik, J. C. Henquin, and J. C. Jonas. High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFκB, Diabetologia, 48:496-505 (2005).
PubMed 15739117

A. K. Cardozo, F. Ortis, J. Storling, Y. M. Feng, J. Rasschaert, M. Tonnesen, F. Van Eylen, T. Mandrup-Poulsen, A. Herchuelz, and D. L. Eizirik. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca²⁺ ATPase 2b and deplete endoplasmic reticulum Ca²⁺, leading to induction of endoplasmic reticulum stress in pancreatic β-cells, Diabetes, 54:452-461 (2005).
PubMed 15677503

C. A. Gysemans, A. K. Cardozo, H. Callewaert, A. Giulietti, L. Hulshagen, R. Bouillon, D. L. Eizirik, and C. Mathieu. 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice, Endocrinology, 146:1956-1964 (2005).
PubMed 15637289

L. J. Smink, E. M. Helton, B. C. Healy, C. C. Cavnor, A. C. Lam, D. Flamez, O. S. Burren, Y. Wang, G. E. Dolman, D. B. Burdick, V. H. Everett, G. Glusman, D. Laneri, L. Rowen, H. Schuilenburg, N. M. Walker, J. Mychaleckyj, L. S. Wicker, D. L. Eizirik, J. A. Todd, and N. Goodman. T1DBase, a community web-based resource for type 1 diabetes research, Nucleic Acids Res., 33:D544-D549 (2005).
PubMed 15608258

2004

B. Kutlu, N. Naamane, L. Berthou, and D. L. Eizirik. New approaches for in silico identification of cytokine-modified β cell gene networks, Ann. N. Y. Acad. Sci., 1037:41-58 (2004).
PubMed 15699492

A. E. Karlsen, P. E. Heding, H. Frobose, S. G. Ronn, M. Kruhoffer, T. F. Ørntoft, M. Darville, D. L. Eizirik, F. Pociot, J. Nerup, T. Mandrup-Poulsen, and N. Billestrup. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1β-mediated toxicity through inhibition of multiple nuclear factor-κB-regulated proapoptotic pathways, Diabetologia, 47:1998-2011 (2004).
PubMed 15578154

M. De Ridder, V. N. Verovski, M. I. Darville, D. L. Van Den Berge, C. Monsaert, D. L. Eizirik, and G. A. Storme. Macrophages enhance the radiosensitizing activity of lipid A: a novel role for immune cells in tumor cell radioresponse, Int. J. Radiat. Oncol. Biol. Phys., 60:598-606 (2004).
PubMed 15380597

M. Ohara-Imaizumi, A. K. Cardozo, T. Kikuta, D. L. Eizirik, and S. Nagamatsu. The cytokine interleukin-1β reduces the docking and fusion of insulin granules in pancreatic β-cells, preferentially decreasing the first phase of exocytosis, J. Biol. Chem., 279:41271-41274 (2004).
PubMed 15319424

D. Vermijlen, C. Seynaeve, D. Luo, M. Kruhoffer, D. L. Eizirik, T. F. Ørntoft, and E. Wisse. High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells, Eur. J. Immunol., 34:2529-2540 (2004).
PubMed 15307185

I. Kharroubi, L. Ladrière, A. K. Cardozo, Z. Dogusan, M. Cnop, and D. L. Eizirik. Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: role of nuclear factor-κB and endoplasmic reticulum stress, Endocrinology, 145:5087-5096 (2004).
PubMed 15297438

M. I. Darville, S. Terryn, and D. L. Eizirik. An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic β-cells, Endocrinology, 145:1130-1136 (2004).
PubMed 14630716

W. J. Malaisse, L. Ladrière, I. Verbruggen, and R. Willem. Metabolism of 13C-enriched D-fructose in hepatocytes from Goto-Kakizaki rats, Int. J. Mol. Med., 13:697-703 (2004).
PubMed 15067373

2003

D. L. Eizirik, B. Kutlu, J. Rasschaert, M. Darville, and A. K. Cardozo. Use of microarray analysis to unveil transcription factor and gene networks contributing to β cell dysfunction and apoptosis, Ann. N. Y. Acad. Sci., 1005:55-74 (2003).
PubMed 14679040

I. Kharroubi, J. Rasschaert, D. L. Eizirik, and M. Cnop. Expression of adiponectin receptors in pancreatic β cells, Biochem. Biophys. Res. Commun., 312:1118-1122 (2003).
PubMed 14651988

J. Rasschaert, D. Liu, B. Kutlu, A. K. Cardozo, M. Kruhoffer, T. F. Ørntoft, and D. L. Eizirik. Global profiling of double stranded RNA- and IFN-γ-induced genes in rat pancreatic beta cells, Diabetologia, 46:1641-1657 (2003).
PubMed 14600816

A. K. Cardozo, L. Berthou, M. Kruhoffer, T. Ørntoft, M. R. Nicolls, and D. L. Eizirik. Gene microarray study corroborates proteomic findings in rodent islet cells, J. Proteome Res., 2:553-555 (2003).
PubMed 14582652

B. Kutlu, A. K. Cardozo, M. I. Darville, M. Kruhoffer, N. Magnusson, T. Ørntoft, and D. L. Eizirik. Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells, Diabetes, 52:2701-2719 (2003).
PubMed 14578289

A. K. Cardozo, P. Proost, C. Gysemans, M. C. Chen, C. Mathieu, and D. L. Eizirik. IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice, Diabetologia, 46:255-266 (2003).
PubMed 12627325

B. Kutlu, M. I. Darville, A. K. Cardozo, and D. L. Eizirik. Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic β-cells, Diabetes, 52:348-355 (2003).
PubMed 12540607

A. K. Azevedo-Martins, S. Lortz, S. Lenzen, R. Curi, D. L. Eizirik, and M. Tiedge. Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells, Diabetes, 52:93-101 (2003).
PubMed 12502498

P. Courtois, H. Jijakli, L. Ladrière, B. Oguzhan, A. Sener, and W. J. Malaisse. Pharmacodynamics, insulinotropic action and hypoglycemic effect of nateglinide and glibenclamide in normal and diabetic rats, Int. J. Mol. Med., 11:105-109 (2003).
PubMed 12469228